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271 Ovariectomy of ER¬° KO mice prevented accumulation of triglycerides and reduced body fat and adipocyte size, and preserved regular insulin signaling in liver and skeletal muscle, and improved whole body insulin sensitivity and glucose tolerance, suggesting that ER¬°¡¾ and ER¬° have opposite functions on lipid and glucose metabolism, with ER¬° involved in adipogenesis
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